The mighty Mississippi River has captivated travelers for centuries, winding its way through the heart of America from the northernmost reaches of Minnesota down to the Gulf of Mexico. Cruising this legendary waterway offers a unique opportunity to immerse yourself in the history, culture, and natural beauty of the American Heartland.
Mississippi River cruises provide a leisurely and comfortable way to discover the charming small towns, vibrant cities, and stunning landscapes that line the river’s banks. On board these elegantly appointed vessels, you’ll enjoy spacious staterooms, gourmet dining, enriching onshore excursions, and attentive service – all while taking in the ever-changing vistas from the comfort of your floating home.
Moreover, river cruise lines go above and beyond to ensure the safety and comfort of their senior guests, with features like elevator access, walking assistance devices, and special dietary accommodations. Many also offer wellness activities, educational lectures, and enrichment programs tailored to the needs and preferences of mature travelers.
Here’s a look at 9 of the best Mississippi River cruises for seniors, including their itineraries and notable destinations.
1. Southern Charms
Cruise Line: Viking River Cruises
Duration: 8 days / 7 nights
The “Southern Charms” cruise takes passengers on a scenic journey from New Orleans, Louisiana, to Memphis, Tennessee. This cruise showcases the cultural richness of the South, with a focus on music, history, and cuisine. The Viking Mississippi features modern amenities and elegant accommodations, making it a comfortable choice for seniors.
Itinerary:
- Day 1: New Orleans, LA – Embark and explore the vibrant French Quarter, known for its lively atmosphere and delicious cuisine.
- Day 2:Baton Rouge, LA – Visit the Louisiana State Capitol and learn about the state’s history and culture.
- Day 3:Natchez, MS – Discover antebellum mansions and the rich heritage of this historic town.
- Day 4:Vicksburg, MS – Explore Civil War battlefields and museums, including the Vicksburg National Military Park.
- Day 5:Greenville, MS – Experience the local blues scene and visit the B.B. King Museum.
- Day 6:Memphis, TN – Visit Graceland and enjoy the city’s famous music scene.
- Day 7:Memphis, TN – Optional excursions to local attractions, including the National Civil Rights Museum.
- Day 8:Memphis, TN – Disembark and conclude your journey.
2. Upper Mississippi River
Cruise Line: American Cruise Lines
Duration: 9 nights
Description: The “Upper Mississippi River” cruise offers a scenic journey from St. Louis, Missouri, to St. Paul, Minnesota. This cruise highlights the beauty and history of the Upper Mississippi, featuring charming towns and significant historical sites along the way. The American Melody provides spacious accommodations and a relaxed atmosphere, perfect for seniors.
Itinerary:
- Day 1:St. Louis, MO – Embark and explore the iconic Gateway Arch and local attractions.
- Day 2:Alton, IL – Discover the charming town known for its historic architecture and beautiful river views.
- Day 3:Hannibal, MO – Visit the Mark Twain Boyhood Home & Museum and learn about the famous author’s early life.
- Day 4:Burlington, IA – Enjoy local excursions, including visits to historic sites and scenic parks.
- Day 5:Dubuque, IA – Visit the National Mississippi River Museum & Aquarium and enjoy the local arts scene.
- Day 6:La Crosse, WI – Discover the charming river town with its beautiful bluffs and vibrant downtown.
- Day 7:Red Wing, MN – Experience the local pottery history and explore the scenic riverfront.
- Day 8:St. Paul, MN – Disembark and conclude your journey.
3. Mississippi Delta Explorer
Cruise Line: Viking River Cruises
Duration: 8 days / 7 nights
The Mississippi Delta Explorer cruise is perfect for history buffs, culture enthusiasts, and anyone who loves exploring small towns with big stories. This cruise takes you through the heart of the Deep South, where the Mississippi River shaped the region’s history, music, and traditions. Every stop offers a new perspective on American history and culture, from Civil War battlegrounds to the birthplace of the blues.
Itinerary:
- Day 1: Depart from New Orleans, Louisiana. Explore the lively French Quarter and indulge in Creole cuisine.
- Day 2: Visit Darrow, Louisiana, and tour historic plantations that showcase Southern architecture.
- Day 3: Discover St. Francisville and Experience Baton Rouge’s vibrant culture.
- Day 4: Explore Natchez, Mississippi, with its antebellum homes and French heritage.
- Day 5: Visit Vicksburg to delve into Civil War history with guided tours of battlefields.
- Day 6: Enjoy a day in Greenville, Mississippi, known for its rich musical heritage.
- Day 7: Scenic Sailing: Lower Mississippi.
- Day 8: Arrive in Memphis, Tennessee, where you can visit Graceland and enjoy the city’s famous barbecue before disembarking.
Related: The 10 Best U.S. River Cruises for Seniors
Related: The Best Upper Mississippi River Cruises 2025
4. America’s Heartland
Cruise Line: American Cruise Lines
Duration: 12 days
Description: The “America’s Heartland” cruise takes passengers on a scenic journey from St. Louis, Missouri, to St. Paul, Minnesota. This cruise highlights the cultural and historical significance of the Upper Mississippi River while providing a comfortable and enriching experience.
Itinerary:
- Day 1: St. Louis, MO – Embark and explore the Gateway Arch and local attractions.
- Day 2: Alton, IL – Discover the charming town and its historic sites.
- Day 3: Hannibal, MO – Visit the Mark Twain Boyhood Home & Museum.
- Day 4: Quincy, IL – Explore the local history and architecture.
- Day 5: Burlington, IA – Enjoy a leisurely day with local excursions.
- Day 6: Fort Madison, IA – Discover the historic Fort Madison and its significance.
- Day 7: Keokuk, IA – Visit the scenic views and local attractions.
- Day 8: Muscatine, IA – Explore the town known for its pearl button industry.
- Day 9: Davenport, IA – Enjoy the vibrant arts scene and local culture.
- Day 10: Dubuque, IA – Visit the National Mississippi River Museum & Aquarium.
- Day 11: La Crosse, WI – Discover local shops and the beautiful riverfront.
- Day 12: St. Paul, MN – Disembark and conclude your journey.
5. Historic Mississippi River
Cruise Line: American Heritage
Duration: 8 days / 7 nights
Experience the soul of the South on this round-trip journey from the vibrant city of New Orleans. The Historic Mississippi River Cruise explores the cultural richness, historical landmarks, and culinary delights that make the region truly iconic.
Itinerary:
- Day 1: New Orleans, LA – Embark and explore the vibrant French Quarter.
- Day 2: Cruising the Mississippi—enjoy the afternoon rolling on the mighty Mississippi.
- Day 3: Houmas House, Louisiana- Visit this historic plantation, with its sprawling gardens and fascinating history.
- Day 4: Baton Rouge, LA – Discover the state capital and its history.
- Day 5: Natchez, MS – Visit antebellum mansions and learn about local culture.
- Day 6: Vicksburg, MS – Explore Civil War battlefields and museums.
- Day 7: St. Francisville, Louisiana—immerse yourself in small-town charm with a tour of antebellum homes and serene countryside.
- Day 8: New Orleans, Louisiana-Return to New Orleans, where your journey concludes.
Related: The Best Hudson River Cruises: A Guide to Scenic Waterways for Seniors
Related: Discover the Magic of Viking Mississippi River Cruises in 2025
6. The Great River Road
Cruise Line: American Cruise Lines
Duration: 9 nights
Description: The “Great River Road” cruise takes travelers on a scenic journey from St. Louis, Missouri, to Minneapolis, Minnesota. This cruise celebrates the cultural and historical significance of the Mississippi River while providing a comfortable and enriching experience for seniors.
Itinerary:
- Day 1:St. Louis, MO – Embark and explore the iconic Gateway Arch and the vibrant downtown area.
- Day 2:Alton, IL – Discover the charming town known for its historic architecture and beautiful river views.
- Day 3:Hannibal, MO – Visit the Mark Twain Boyhood Home & Museum and learn about the famous author’s early life.
- Day 4:Burlington, IA – Enjoy local excursions, including visits to historic sites and scenic parks.
- Day 5:Fort Madison, IA – Explore the historic Fort Madison and its significance in American history.
- Day 6:Dubuque, IA – Visit the National Mississippi River Museum & Aquarium and enjoy the local arts scene.
- Day 7:La Crosse, WI – Discover the charming river town with its beautiful bluffs and vibrant downtown.
- Day 8:Red Wing, MN – Experience the local pottery history and explore the scenic riverfront.
- Day 9: Minneapolis, MN – Disembark and conclude your journey.
7. Music Cities Cruise
Cruise Line: American Cruise Lines
Duration: 9 days
Description: The “Music Cities Cruise” takes travelers on a captivating journey from Memphis, Tennessee, to Nashville, Tennessee, exploring the musical heritage of the South. This cruise combines the beauty of the Mississippi River with the vibrant sounds of iconic music cities, offering a rich cultural experience.
Itinerary:
- Day 1:Memphis, TN – Embark and explore the birthplace of blues and rock ‘n’ roll. Visit Beale Street, known for its live music and vibrant atmosphere.
- Day 2:Cruising the Mississippi River – Enjoy onboard entertainment featuring local musicians while taking in the scenic views of the river.
- Day 3:Paducah, KY – Discover the historic town known for its murals and the National Quilt Museum. Learn about the region’s rich cultural heritage.
- Day 4:Cruising Lake Barkley – Relax as you cruise through the scenic landscapes of Lake Barkley and the Cumberland River, with opportunities for wildlife viewing.
- Day 5:Clarksville, TN – Explore the charming town and visit Fort Defiance, which played a significant role during the Civil War.
- Day 6:Nashville, TN – Experience the vibrant music scene, visit the Country Music Hall of Fame, and enjoy a live show at the Grand Ole Opry.
- Day 7:Nashville, TN – Optional excursions to local attractions, including historic neighborhoods and music venues.
- Day 8:Cruising the Cumberland River – Enjoy onboard activities and relaxation as you cruise back to Memphis.
- Day 9:Memphis, TN – Disembark and conclude your journey.
8. Heartland of America
Cruise Line: Viking River Cruises
Duration: 8 days / 7 nights
The Heartland of America cruise takes you deep into the cultural and historical fabric of the Midwest and Southern United States. This itinerary is perfect for travelers seeking a blend of natural beauty, historic sites, and authentic local experiences.
Itinerary:
- Day 1: St. Louis, Missouri – Marvel at the Gateway Arch and dive into the city’s dynamic food scene.
- Day 2: Hannibal, Missouri – Immerse yourself in Mark Twain’s boyhood home and literary legacy.
- Day 3: Dubuque, Iowa – Tour the National Mississippi River Museum & Aquarium and enjoy the town’s historic charm.
- Day 4: Burlington, Iowa – Stroll Snake Alley.
- Day 5: Quad Cities – Visit iconic landmarks and explore the area’s thriving arts scene.
- Day 6: La Crosse, Wisconsin – Discover scenic bluffs and the area’s rich brewing heritage.
- Day 7: Red Wing, Minnesota – Explore this picturesque town with its renowned pottery and antique shops.
- Day 8: St. Paul, Minnesota – Bid farewell to your fellow guests and journey home.
9. Lower Mississippi River
Cruise Line: American Cruise Lines
Duration: 7 nights
Description: The “Lower Mississippi River” cruise takes travelers from New Orleans to Memphis, focusing on the rich history and culture of the region. This cruise offers a relaxing journey with modern amenities and spacious accommodations aboard the American Heritage.
Itinerary:
- Day 1:New Orleans, LA – Embark and explore the vibrant city, including the French Quarter and local cuisine.
- Day 2:Oak Alley Plantation, LA – Tour the historic plantation, famous for its stunning oak trees and antebellum architecture.
- Day 3:Baton Rouge, LA – Discover local history and attractions, including the Capitol and the Louisiana State Museum.
- Day 4:Natchez, MS – Visit antebellum homes and learn about the region’s plantation history.
- Day 5:Vicksburg, MS – Explore Civil War sites and museums, including the Vicksburg National Military Park.
- Day 6:Memphis, TN – Experience the music scene and visit Graceland, the home of Elvis Presley.
- Day 7:Memphis, TN – Optional excursions and onboard activities.
- Day 8:Memphis, TN – Disembark and conclude your journey.
The best times of year to take a Mississippi River cruise
The best times of year to take a Mississippi River cruise for seniors depend on personal preferences for weather, scenery, and activities. Here’s a breakdown of the ideal seasons for cruising along this iconic waterway:
1. Spring (March to May)
Spring is a magical time to cruise the Mississippi River, as the landscape comes alive with blooming flowers and mild temperatures.
– Beautiful blossoms and greenery along the riverbanks.
– Mild weather makes exploring historic towns and cities comfortable.
– Fewer crowds than peak summer months allow for a more intimate experience.
Spring cruises often include visits to local gardens, historic sites, and charming towns, making it an excellent time for sightseeing and photography.
2. Summer (June to August)
Summer is one of the most popular seasons for Mississippi River cruises, attracting many travelers looking for warm weather and vibrant experiences.
– Long, sunny days with plenty of opportunities for outdoor activities.
– Lush greenery along the banks and lively city atmospheres.
– Extended daylight hours create an amazing ambiance for evening events.
Summer cruises often feature onboard entertainment, outdoor dining options, and excursions to local attractions. It’s also a great time for festivals and events in various towns along the river.
3. Fall (September to November)
Fall is arguably the most picturesque time to cruise the Mississippi River, as the landscape transforms into a vibrant tapestry of autumn colors.
– Stunning fall foliage creates breathtaking views along the river.
– Pleasant temperatures make it comfortable for outdoor exploration.
– Local harvest festivals add a cultural touch to your cruise experience.
Fall cruises typically include excursions to wineries and farms, where travelers can participate in seasonal activities like apple picking or wine tasting. The changing colors of the leaves provide a stunning backdrop for scenic cruising.
4. Winter (December to February)
While winter may not be as popular as other seasons, it offers a unique charm for those willing to embrace the cold.
– Serene beauty with snow-dusted landscapes creates a peaceful atmosphere.
– Fewer tourists mean more intimate experiences at popular destinations.
– Holiday-themed cruises can include festive decorations and special events.
Winter cruises may feature visits to holiday markets or winter festivals. Some cruises offer cozy onboard amenities like hot cocoa and warm meals to enhance the experience.
Need information on Lower Mississippi cruise for May, 2025. One person, room with a deck.
There are cruises during May on board the ship American Melody: May 2, 2025 | May 9, 2025 | May 16, 2025
9 Days & 8 Nights, from New Orleans to Memphis
details: https://usarivercruises.com/cruise/lower-mississippi-river-cruise-new-orleans-memphis-3-2-2-2/